NIELS BOHR INSTITUTE

UNIVERSITY OF COPENHAGEN

OPTICAL

TWEEZERS

biophysical research group


FNU project

Facts

Description

People

Publications

Outreach

Jobs

Force mapping during cancer cell division and invasion

Facts about the project:

Granting agency: Det Frie Forskningsraad (Danish Council for Independent Research).
Grant type: DFF-Forskningsprojekt 2.
Amount granted: 6.064.476 Dkr.
Project period: July 2014 - December 2017.

Project description

Cells respond to both biochemical and mechanical cues in their microenvironment. Extrinsic mechanical stimuli regulate intrinsic cellular biochemical signaling, regulating cellular evolution, motility and fate. The mechanical properties of the cell itself also influence the surrounding microenvironment. The project focuses on the mechanics of cancer cell invasion, both in terms of how cancer cells differ from non-cancerous cells, and the mechanical interaction between cancer cells and the microenvironment. Cancer cells are deadly once they cross the endothelial barrier of the blood stream, invade into local and distant tissue, and proliferate in vital organs. Thus, we will focus on mapping the mechanical forces and dynamics associated with these processes to better understand the mechanisms and uncover potential avenues of inhibition.

People involved

PI: Lene B. Oddershede (Assoc. Prof., Group Leader), Niels Bohr Institute, University of Copenhagen.
co-PI: Janine T. Erler (Assoc. Prof., Group Leader), BRIC, University of Copenhagen.

Publications

All publications related to this project will be published open access and will be available on this homepage.

Outreach

Communication to the public regarding the project's exciting findings will be mediated by Gertie Skaarup, Head of the NBI communication office, phone +45 353-25320.
Our previous and parallel investigations of the physics of cancer are demonstrated in this movie.

Jobs

See announcement of our first PhD position (with enrollment at the Niels Bohr Institute) via this link: PhD position announcement
A second PhD position (with enrollment at BRIC) will soon be announced on this homepage.