Force mapping during cancer cell division and invasion
Facts about the project:
Granting agency: Det Frie Forskningsraad (Danish Council for Independent Research)
July 2014 - December 2017.
Cells respond to both biochemical and mechanical cues in their microenvironment. Extrinsic mechanical stimuli regulate intrinsic cellular biochemical signaling, regulating cellular evolution, motility and fate. The mechanical properties of the cell itself also influence the surrounding microenvironment. The project focuses on the mechanics of cancer cell invasion, both in terms of how cancer cells differ from non-cancerous cells, and the mechanical interaction between cancer cells and the microenvironment. Cancer cells are deadly once they cross the endothelial barrier of the blood stream, invade into local and distant tissue, and proliferate in vital organs. Thus, we will focus on mapping the mechanical forces and dynamics associated with these processes to better understand the mechanisms and uncover potential avenues of inhibition.
PI: Lene B. Oddershede
(Assoc. Prof., Group Leader), Niels Bohr Institute, University of Copenhagen.
co-PI: Janine T. Erler
(Assoc. Prof., Group Leader), BRIC, University of Copenhagen.
All publications related to this project will be published open access and will be available on this homepage.
Communication to the public regarding the project's exciting findings will be mediated by Gertie Skaarup, Head of the NBI communication office, phone +45 353-25320.
Our previous and parallel investigations of the physics of cancer are demonstrated in
See announcement of our first PhD position (with enrollment at the Niels Bohr Institute) via this link: PhD position announcement
A second PhD position (with enrollment at BRIC) will soon be announced on this homepage.